In this chapter we highlight the influence of visual saliency, or local contrast, on users’ searches of interfaces. Designers have traditionally focused on the importance of goals and expectations (top-down processes) for the navigation of interfaces with little consideration for the influence of saliency (bottom-up processes). The Human-Computer Interaction literature does not discuss the influence of bottom-up processing, potentially neglecting an important aspect of interface-based searches. We review studies that demonstrate how a user’s attention is rapidly drawn to visually salient locations in a variety of tasks and scenes, including web pages.